{"id":484607,"date":"2021-11-30T13:27:23","date_gmt":"2021-11-30T12:27:23","guid":{"rendered":"https:\/\/www.tomhemps.com\/?p=484607"},"modified":"2023-03-22T12:47:27","modified_gmt":"2023-03-22T11:47:27","slug":"the-endocannabinoid-system","status":"publish","type":"post","link":"https:\/\/www.tomhemps.com\/en\/blog\/the-endocannabinoid-system\/","title":{"rendered":"The endocannabinoid system"},"content":{"rendered":"<h2><strong>The endocannabinoid system &#8211; A trip into our body\u00a0<\/strong><\/h2>\n<p>In for a penny, in for a pound \u2013 that\u2019s just how it is with<strong> CBD and the endocannabinoid system<\/strong>. If you\u2019re into the former, you should know at least some basics of the latter. Knowledge is the new black; you know how it is. If you\u2019ve never heard of the endocannabinoid system or feel like to expand your knowledge of it a bit, you\u2019ve come to the right place!<\/p>\n<p>In the following, we\u2019ll have a look at what this system is, how we came to know it exists and how your daily <a href=\"https:\/\/www.tomhemps.com\/en\/your-ideal-cbd-dosage-cbd-oil-cbd-capsules-and-co\/\">dose of CBD<\/a> may or may not influence it.<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>Back to the roots \u2013 literally. <\/strong><\/h3>\n<p>Back in 2007, when will.i.am released the song \u2018I got it from my mama\u2019 the lyricist probably didn\u2019t have the endocannabinoid system in mind, but it very much <em>could<\/em> be the soundtrack to the present topic. Not only you have this system, but your mama, and her mama, and her mama\u2019s mama \u2013 you see where this is going.<\/p>\n<p>The endocannabinoid system is deeply embedded in our <strong>genetics<\/strong>, as it is part of our nervous system. The prefix \u2018endo\u2019 hints at this: it\u2019s Greek and can be translated to \u2018within\u2019. So: the endocannabinoid system is endogenous. Within our nervous system, there are so-called <strong>cannabinoid receptors<\/strong>, with which the <strong>active ingredients of the cannabis plant<\/strong> can connect.<\/p>\n<p>Endocannabinoids are our own <strong>molecules<\/strong>, which serve as messenger substances and can connect to those receptors as well. We\u2019ll get more into that in a bit \u2013 for now, we want to focus on the basics.<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>CB1 and CB2 \u2013 receptors on fire<\/strong><\/h3>\n<p>There are quite a few cannabinoid receptors, but the true stars are the receptors <em>CB1 and CB2<\/em>.\u00a0 What may sound like C3PO\u2019s siblings from Star Wars, actually are the receptors which are responsible for many processes within our body. Endocannabinoids that affect the CB1 receptor positively <strong>influence the interconnectedness of nerve cells<\/strong> \u2013 which are important for our brain development.<\/p>\n<p>According to studies, endocannabinoids are mainly released in <strong>stressful situations<\/strong>. They then connect to CB1, resulting into a pain-relieving effect. While this is without a doubt an incredibly important characteristic, without which we would probably suffer a lot more pain, CB1 has a lot more to offer: it <strong>regulates symptoms<\/strong> of withdrawal, eases anxiety, keeps our brain safe after injuries and quickens our appetite \u2013 yummy! By the way \u2013 when this was discovered, scientists developed a CB1 blocker to help treating obesity \u2013 how cool is that?!<\/p>\n<p>The CB2 receptor is pretty cool as well, though \u2013 it helps turning our body into the fighting machine it is. CB2 has so many effects and connected processes, that it is still the focus of research to this day. The receptor is found in our <strong>peripheral and central nervous system<\/strong>, on numerous <strong>cells of the immune system<\/strong> and <strong>gastrointestinal tract<\/strong>.<\/p>\n<p>No idea what any of that means? Don\u2019t worry, we got you: CB2 affects bowel, kidneys, pancreas, fat tissue, skeletal muscles, bones, eyes, tumors, reproductive organs, immune system, airways, skin, central nervous system, cardiovascular system and liver. On all these regions and organs, CB2 has an anti-inflammatory effect, when connected to endocannabinoids. Very impressive, don\u2019t you think?<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>Throwback to when the endocannabinoid system was discovered<\/strong><\/h3>\n<p>So, with all these positive effects the endocannabinoid system has on our bodies, let\u2019s have a look at whom we can thank for this knowledge. In the 1960s, the Israeli researchers <em>Raphael Mechoulam<\/em> and <em>Yehiel Gaoni<\/em> were able to determine that THC is one of the most important psychoactive substances found in the cannabis plant.<\/p>\n<p>This discovery paved the way for scientists in the 1990s, who were able to identify the receptors the THC connects to \u2013 which are, you guessed correctly, the CB1 and CB2 receptors. Because of this, they found out that there are endogenous cannabinoids, made up of <strong>omega 6 fatty acids<\/strong>.<\/p>\n<p>They called their finding anandamide \u2013 derived from the Sanskrit word \u2018ananda\u2019 which means bliss or happiness. Their research and findings have had a major impact on research on cannabinoids and our body.<\/p>\n<p>&nbsp;<\/p>\n<h3><strong>CBD and the endocannabinoid system<\/strong><\/h3>\n<p>Now, that we know the basics, we can turn to our last chapter for today: since THC has an influence on the <strong>cannabinoid receptors<\/strong>, does CBD have that effect as well? It\u2019s safe to say: yes! We know for sure that CBD (which is short for cannabidiol, btw) has effects on the body via the endocannabinoid system.<\/p>\n<p>For example, <a href=\"https:\/\/www.tomhemps.com\/en\/cbdictionary\/cbd-oil\/\">using CBD oil<\/a> can shift your well-being to the realm of the positive. Also, CBD blocks certain enzymes which usually <strong>decompose endocannabinoids<\/strong>, meaning that it helps keeping our endocannabinoid system intact.<\/p>\n<p>Since research in this area only started about two decades ago, there is still a lot that we don\u2019t know, but more than ever are <strong>researchers and scientists<\/strong> invested to solve the mysteries around the endocannabinoid system and how it affects our body. If you\u2019re interested in this kind of stuff and would like to know more, we can only advise you to check out our blog \u2013 you\u2019ll find lots of articles on current <strong>CBD topics<\/strong>!<\/p>\n<p><small>Photo: Kym MacKinnon \/ <a href=\"https:\/\/unsplash.com\/\" target=\"_blank\" rel=\"noopener\">Unsplash<\/a><\/small><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":8574,"featured_media":484764,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1493],"tags":[391,417,2333,2335,2354,2474,2476,2615],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v22.8 (Yoast SEO v22.8) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The endocannabinoid system - A trip into our body | Tom Hemp&#039;s Blog<\/title>\n<meta name=\"description\" content=\"Your CBD Shop | Your CBD Brand | born in Berlin - The endocannabinoid system\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.tomhemps.com\/en\/blog\/the-endocannabinoid-system\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The endocannabinoid system\" \/>\n<meta property=\"og:description\" content=\"Your CBD Shop | Your CBD Brand | born in Berlin - 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